|
| Status |
Public on Feb 06, 2012 |
| Title |
Genome-wide maps of Egr2 transcription factor binding sites in NKT and anti TCRb injected thymocytes. |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We report the application of single-molecule-based sequencing technology for mapping the Egr2 transcriptional program in developing thymic NKT. We found that Egr2 controls the induction of genes required for NKT development.
|
| |
|
| Overall design |
Examination of developing NKT cells and thymocytes receiving a strong TCR signal in vivo by injecting 500ug anti-TCRb antibody.
|
| |
|
| Contributor(s) |
Seiler MP, Mathew RM, Liszewski MK, Sponer C, Barr K, Meng F, Singh H, Bendelac A |
| Citation(s) |
22306690 |
| Submission date |
Dec 08, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Michael Paul Seiler |
| E-mail(s) |
mseiler@bsd.uchicago.edu
|
| Phone |
773-702-9196
|
| Fax |
773-834-1999
|
| Organization name |
University of Chicago
|
| Department |
Committee on Immunology
|
| Lab |
Bendelac
|
| Street address |
929 E 57th Street
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
|
| Samples (4)
|
|
| Relations |
| SRA |
SRP009652 |
| BioProject |
PRJNA149755 |
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