|
| Status |
Public on Dec 10, 2011 |
| Title |
Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by array
|
| Summary |
In this study three Indian rhesus macaques were infected with Simian Immunodeficiency Virus (SIVmac251). This generates a chronic infection mirroring AIDS in the animals. Prior to infection (day 0) and at two different time-points post-infection (day 21 and day 90), intestinal resection biopsies were performed. The intestinal tissue was then separated into different sub-sections including lamina-propria lymphocytes (LPL), intra-epithelial lymphocytes (IEL), stroma or matrix and epithelium. In this study we report the genome-wide transcriptional response at the two different time-points, specific to LPL, relative to pre-infection samples. For this purpose we have used the Affymetrix Rhesus Macaque GeneChip.
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| |
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| Overall design |
3 Rhesus Macaques prior to infection and 21 and 90 days of infection
|
| |
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| Contributor(s) |
Kaushal D, Mohan M, Lackner A |
| Citation(s) |
22511950 |
| Submission date |
Dec 09, 2011 |
| Last update date |
Aug 27, 2019 |
| Contact name |
Deepak Kaushal |
| E-mail(s) |
dkaushal@tulane.edu
|
| Organization name |
Tulane National Primate Research Center
|
| Department |
Bacteriology
|
| Lab |
Kaushal
|
| Street address |
18703 Three Rivers Rd
|
| City |
Covington |
| State/province |
LA |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL3535 |
[Rhesus] Affymetrix Rhesus Macaque Genome Array |
|
| Samples (9)
|
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| Relations |
| BioProject |
PRJNA151521 |
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