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Series GSE34355 Query DataSets for GSE34355
Status Public on Dec 13, 2011
Title Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma [Illumina Infinium HumanMethylation27 Beadchip v1.2]
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Medulloblastoma, the most common malignant pediatric brain tumour, disseminates by shedding cells into the cerebrospinal fluid, which then re-implant to cover the surface of the brain and spinal cord. Metastases are a very poor prognostic sign at presentation and are usually lethal at recurrence. Mechanisms driving dissemination have been described in the bulk primary tumour, with the underlying assumption that primary tumour and metastases are biologically similar. Here we show that in both mouse and human medulloblastoma, multiple metastases from a single animal are extremely similar, but are genetically highly divergent from the primary tumour. Clonal genetic events in the metastases can be demonstrated in a restricted sub-clone of the primary tumour, suggesting that only rare cells within the primary tumour have the ability to metastasize. Failure to account for the bicompartmental nature of primary and metastatic medulloblastoma represents a major barrier to the development of effective targeted therapies.
 
Overall design DNA methylation analysis of 15 pediatric medulloblastoma samples consisting of 6 primary-metastatic pairs and 4 normal cerebella samples profiled in Illumina Infinium HumanMethylation27 Beadchip v1.2
 
Contributor(s) Dubuc AM, Wu X, Taylor MD
Citation(s) 22343890
Submission date Dec 12, 2011
Last update date Jan 02, 2015
Contact name Paul A. Northcott
E-mail(s) panorthcott@gmail.com
Organization name German Cancer Research Center (DKFZ)
Street address Im Neuenheimer Feld 280
City HEIDELBERG
ZIP/Postal code 69120
Country Germany
 
Platforms (1)
GPL8490 Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)
Samples (19)
GSM847677 MB-527
GSM847678 MB-528
GSM847679 MB-529
This SubSeries is part of SuperSeries:
GSE34356 Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma
Relations
BioProject PRJNA156399

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE34355_Matrix_signal_intensities.txt.gz 2.8 Mb (ftp)(http) TXT
GSE34355_RAW.tar 5.8 Mb (http)(custom) TAR
Processed data included within Sample table

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