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| Status |
Public on Aug 02, 2012 |
| Title |
The role of Foxp1/4 in lung development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Foxp1/4 transcription factors are conserved transcriptional repressors expressed in overlapping patterns during lung development as well as in the adult lung. However, the role of Foxp1/4 in development and homeostasis of the pseudostratified epithelium of the proximal airways and trachea is unknown.
We propose to determine the roles for Foxp1/4 in lung development by deleting these genes in lung epithelial specific knockout mice.
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| Overall design |
To explore the genome wide consequences of Foxp1/4 deficiency on secretory epithelial differentiation in the lung, we performed microarray analysis of Shh- cre control and Foxp1/4ShhcreDKO mutants lungs at E14.5, 3 embryos, respectively.
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| Contributor(s) |
Li S, Wang Y, Zhang Y, Lu MM, DeMayo F, Dekker J, Tucker P, Morrisey E |
| Citation(s) |
22675208 |
| Submission date |
Dec 20, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Shanru Li |
| E-mail(s) |
shanruli@mail.med.upenn.edu
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| Phone |
001-215-573-7052
|
| Fax |
001-215-573-2094
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| Organization name |
University of Pennsylvania
|
| Department |
Medicine
|
| Lab |
Edward Morrisey
|
| Street address |
3400 Civic Center Blvd, Bldg 421
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| GSM851596 |
Lung Shh-cre:Foxp1flox/flox:Foxp4flox/flox(Mut1) |
| GSM851597 |
Lung Shh-cre:Foxp1flox/flox:Foxp4flox/flox(Mut2) |
| GSM851598 |
Lung Shh-cre:Foxp1flox/flox:Foxp4flox/flox(Mut3) |
|
| Relations |
| BioProject |
PRJNA151001 |
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