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Series GSE34763 Query DataSets for GSE34763
Status Public on Apr 04, 2013
Title SOX11 Gene Expression Profiling
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The neural transcription factor SOX11 is overexpressed in aggressive lymphoid neoplasms mainly in mantle cell lymphoma (MCL), but its functional role in malignant B-cells is unknown. To identify target genes transcriptionally regulated by SOX11 in malignant lymphoid cells, we have used Gene Expression Profiling (GEP) after SOX11 silencing in MCL cell lines.
Overall design Differential gene expression between Z138-shSOX11 and Z138-shControl MCL cell lines.

To determine the transcriptional programs regulated by SOX11, we first generated an MCL cellular model with reduced SOX11 protein levels by infecting MCL cell lines with lentiviral particles carrying shRNA plasmids specifically targeting SOX11 (shSOX11.1 and shSOX11.3). Next, we compared the GEP of shSOX11 and shControl Z138 stable transduced clones using the Affymetrix U133+2.0 microarrays.
Contributor(s) Vegliante MC, Palomero J, Jares P, Campo E, Amador V
Citation(s) 23321250, 25092176
Submission date Dec 28, 2011
Last update date Mar 25, 2019
Contact name Virginia Amador
Phone +34 932275400
Fax +34 932275717
Organization name IDIBAPS
Street address Rossello 153
City Barcelona
ZIP/Postal code 08036
Country Spain
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (4)
GSM854802 Z138-shControl.1
GSM854803 Z138-shControl.2
GSM854804 Z138-shSOX11.1
BioProject PRJNA150359

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE34763_RAW.tar 18.4 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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