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Series GSE34901 Query DataSets for GSE34901
Status Public on Apr 26, 2012
Title Expression data from mouse lungs during E. coli pneumonia in the presence or absence of LIF neutralization
Organism Mus musculus
Experiment type Expression profiling by array
Summary Leukemia inhibitory factor (LIF) is amongst the IL-6 family cytokines expressed in the lungs during pneumonia. However, the function of endogenous LIF during pneumonia has never been explored. The purpose of this study was to determine the transcriptional response to pneumonia in the lungs and whether or how this response is influenced by LIF.
Mice received intratracheal instillations of vehicle (PBS) or Escherichia coli (10^6 CFU). Control IgG or anti-LIF specific IgG was included in the instillate. 24 hours after the challenge, lungs were collected for RNA isolation and microarray analysis.
 
Overall design RNA from 3 separate groups of mice (3 mice per group) was analyzed: 1) 24h Vehicle/control IgG-treated; 2) 24h E. coli/control IgG-treated; and 3) 24h E. coli/anti-LIF-specific IgG.
 
Contributor(s) Quinton LJ
Citation(s) 22581855
Submission date Jan 06, 2012
Last update date May 17, 2012
Contact name Lee Quinton
Organization name Boston University School of Medicine
Street address 72 E Concord St
City Boston
State/province MA
ZIP/Postal code 02118
Country USA
 
Platforms (1)
GPL11078 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [CDF: MoGene10stv1_Mm_ENTREZG_13]
Samples (9)
GSM857302 Uninfected control IgG-treated lungs, biological rep1
GSM857303 Uninfected control IgG-treated lungs, biological rep2
GSM857304 Uninfected control IgG-treated lungs, biological rep3
Relations
BioProject PRJNA150175

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE34901_RAW.tar 53.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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