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| Status |
Public on Jul 17, 2013 |
| Title |
Genome-wide analysis of GW3965-responsive genes in 4 different breast cancer cell lines, MCF-7, T-47D, SK-BR-3, and MDA-MB-231 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of differentially expressed genes in response to the LXR agonist GW3965 in the MCF-7, T-47D, SK-BR-3, and MDA-MB-231 breast cancer cell lines. It was previously reported that GW3965 has antiproliferative effects on these 4 different breast cancer cell lines. In the present study, we additionally determine the effects of the LXR ligand on breast cancer cells and determine their mechanism of action in reducing cell proliferation.
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| Overall design |
Total RNA obtained from 4 different breast cancer cell lines (MCF-7, T-47D, SK-BR-3, MDA-MB-231) grown in culture treated with ethanol (control) or GW3965 (GW-treated, experimental) for 48 hours. Triplicates were performed.
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| Contributor(s) |
Lin CY, Vu T |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 10, 2012 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Trang Vu |
| E-mail(s) |
htrangtvu@gmail.com
|
| Organization name |
The University of Houston
|
| Department |
The Center for Nuclear Receptors and Cell Signaling
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| Lab |
Chin-Yo Lin
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| Street address |
3605 Cullen Blvd., SERC Bldg 545
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77204 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA151087 |
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