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Series GSE35088 Query DataSets for GSE35088
Status Public on May 01, 2012
Title Regulation of gene expression with thyorid hormone in rats with myocardial infarction
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Thyroid hormone improves left ventricular remodeling and cardiac performance after myocardial infarction (MI), but the molecular basis is unknown. This study was designed to detect gene expression changes in left ventricular non-infarcted areas at 4 weeks following myocardial infarction with and without thyroid hormone treatment. The results suggest that altered expression of genes for molecular function and biological process may be involved in the beneficial effects of thyroid hormone treatment following myocardial infarction in rats.
 
Overall design MI was produced by ligation of the left anterior descending coronary artery in female SD rats. Rats were divided into the following groups: (1) Sham MI, (2) MI, and (3) MI+T4 treatment (T4 pellet 3.3mg, 60 days release, implanted subcutaneously immediately following MI). Four weeks after surgery, total RNA was isolated from left ventricular non-infarcted areas for microarray analysis using the Illumina RatRef-12 Expression BeadChip Platform.
 
Contributor(s) Yuefeng C, Pottala JV, Weltman NY, Ge X, Savinova OV, Gerdes AM
Citation(s) 22870193
Submission date Jan 13, 2012
Last update date Nov 12, 2022
Contact name Xijin Ge
E-mail(s) xijin.ge@sdstate.edu
URL http://bioinformatics.sdstate.edu
Organization name South Dakota State University
Department Mathematics and Statistics
Street address SDSU box 2220C
City Brookings
State/province SD
ZIP/Postal code 57006
Country USA
 
Platforms (1)
GPL6101 Illumina ratRef-12 v1.0 expression beadchip
Samples (24)
GSM861837 sham biological rep 1 technical rep 1
GSM861838 sham biological rep 1 technical rep 2
GSM861839 sham biological rep 2 technical rep 1
Relations
BioProject PRJNA150923

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE35088_RAW.tar 2.8 Mb (http)(custom) TAR
GSE35088_non_normalized.txt.gz 2.1 Mb (ftp)(http) TXT
Processed data included within Sample table

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