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Series GSE35090 Query DataSets for GSE35090
Status Public on May 25, 2014
Title Genome-wide analysis of gene expression changes in mouse keratinocytes induced by treatment with DAPT
Organism Mus musculus
Experiment type Expression profiling by array
Summary Analysis of gene expression changes that occur in keratinocytes during reprogramming when they are treated with DAPT, a small molecule gamma-secretase inhibitor. The hypothesis tested in the present study was that Notch inhibition by DAPT treatment would promote reprogramming by inhibiting p21 activity while leaving p53 expression intact. Results provide important information of the gene expression changes in response to DAPT treatment, such as changes in the expression of p21, p21-responsive genes, p53, p53-responsive genes involved in apoptosis, and Notch-responsive genes.
 
Overall design Total RNA obtained from mouse keratinocytes transduced with reprogramming transcription factors and treated or not treated with DAPT for 4 days or 7 days.
 
Contributor(s) Ichida J
Citation(s) 24952596
Submission date Jan 13, 2012
Last update date Jun 14, 2018
Contact name Justin Ichida
E-mail(s) cheeda1@gmail.com
Phone 6172717366
Organization name University of Southern California
Street address 1425 San Pablo St. Bcc 307
City Los Angeles
State/province CA
ZIP/Postal code 90033
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (4)
GSM861861 no DAPT, day 4
GSM861862 2.5 uM DAPT, day 4
GSM861863 no DAPT, day 7
Relations
BioProject PRJNA150909

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE35090_RAW.tar 3.1 Mb (http)(custom) TAR
GSE35090_non-normalized.txt.gz 758.5 Kb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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