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| Status |
Public on Oct 28, 2005 |
| Title |
Fat-type specific effects of high fat diets |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
High fat diet (HF) rodent models have contributed significantly to the dissection of the pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly between different studies. Here, we have analyzed gene expression patterns in livers of animals fed with different HF with varying fatty acid compositions.
Keywords: diet-gene interaction
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| Overall design |
Male Wistar rats were fed with high fat diets (42 energy%, fat sources: lard, olive oil; coconut fat; cod liver oil). Weight, food intake, whole body insulin tolerance and plasma parameters of glucose and lipid metabolism were measured during a 12 week diet course. Liver histologies and hepatic gene expression profiles using AffymetrixR gene chips were obtained.
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| Contributor(s) |
Buettner R, Parhofer K, Woenckhaus M, Wrede CE, Kunz-Schughart LA, Scholmerich J, Bollheimer LC |
| Citation(s) |
16720718 |
| Submission date |
Oct 26, 2005 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Roland Buettner |
| E-mail(s) |
roland.buettner@klinik.uni-r.de
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| Phone |
0049-941-944-7003
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| Fax |
0049-041-944-7004
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| Organization name |
University of Regensburg
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| Department |
Internal Medicine I
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| Lab |
Endocrinology
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| Street address |
Franz-Josef-Strauss-Allee 11
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| City |
Regensburg |
| ZIP/Postal code |
93042 |
| Country |
Germany |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (10)
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| GSM78872 |
fasted liver olive oil diet 2 |
| GSM78873 |
fasted liver coconut fat diet 1 |
| GSM78874 |
fasted liver coconut fat diet 2 |
| GSM78875 |
fasted liver fish oil diet 1 |
| GSM78876 |
fasted liver fish oil diet 2 |
| GSM78877 |
fasted liver standard chow diet 1 |
| GSM78878 |
fasted liver standard chow diet 2 |
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| Relations |
| BioProject |
PRJNA93555 |
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