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Series GSE35148 Query DataSets for GSE35148
Status Public on Dec 31, 2014
Title Genome-wide analysis of P15 dorsal root ganglion gene expression of control and Isl1-Cre//c-Maf mutant mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary The sense of touch relies on the detection of mechanical stimuli by specialized sensory neurons. Mechanosensory neurons are generated from neural crest cells, but the scarcity of molecular data has made it difficult to analyze their development and to define the basis of their diversity and function. The transcription factor c-Maf is crucial for mechanosensory function in mice and humans. In particular, c-Maf is required for the development and function of mechanosensory neurons terminating in lanceolate endings, Meissner corpuscles and Pacinian corpuscles. c-Maf is a key transcription factor directing the development and function of rapidly-adapting mechanoreceptors and their end organs.
 
Overall design Total RNA of pools from L3,4,5,6 DRGs of 15-day-old control mice was compared to total RNA of pools from L3,4,5,6 DRGs of 15-day-old Isl1-Cre//c-Maf conditional mutant mice.
 
Contributor(s) Wende H, Birchmeier C
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jan 17, 2012
Last update date Jun 14, 2018
Contact name Hagen Wende
Organization name Heidelberg University
Department Institute of Pharmacology
Lab Siemens
Street address Im Neuenheimer Feld 366
City Heidelberg
ZIP/Postal code 69120
Country Germany
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (12)
GSM862619 control #1
GSM862620 control #2
GSM862621 control #3
Relations
BioProject PRJNA150765

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE35148_RAW.tar 3.1 Mb (http)(custom) TAR
GSE35148_non-normalized.txt.gz 2.0 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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