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| Status |
Public on Apr 13, 2012 |
| Title |
Hepatic gene expression in C57BL/6 mice intratracheally instilled with Printex 90 carbon black nanoparticles |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We investigated hepatic mRNA profiles of female mice exposed to 0.162 mg Printex 90 carbon black nanoparticles by single intra-tracheal instillation. We examined responses to this dose 1, 3 and 28 days after exposure, alongside respective controls. We show that genes part of the 3-hydroxy-3-methyl-glutaryl-CoA reductase pathway to be up-regulated by exposure to Printex 90.
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| Overall design |
individual total RNA (200 ng) from 6 mice per treatment group (control and 0.162mg) and universal reference total RNA (Stratagene, Mississauga, ON, Canada) was used to synthesize double stranded cDNA.
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| Contributor(s) |
Bourdon J, Saber A, Williams A, Jacobsen N, Halappanavar S, Wallin H, Yauk C, Vogel U |
| Citation(s) |
22461453, 23146762 |
| Submission date |
Jan 18, 2012 |
| Last update date |
Apr 13, 2020 |
| Contact name |
Andrew Williams |
| Organization name |
Health Canada
|
| Street address |
50 Columbine
|
| City |
Ottawa |
| State/province |
ON |
| ZIP/Postal code |
K1A OK9 |
| Country |
Canada |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (30)
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| This SubSeries is part of SuperSeries: |
| GSE35284 |
Gene expression in C57BL/6 mice intratracheally instilled with Printex 90 carbon black nanoparticles |
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| Relations |
| BioProject |
PRJNA155961 |
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