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Status |
Public on Sep 24, 2012 |
Title |
Expression data from trisomy 21 and euploid induced pluripotent stem cell hematopoietic progenitors |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
|
Summary |
We modeled human Trisomy 21 primitive hematopoiesis using induced pluripotent stem cells (iPSCs). Primitive multipotent progenitor populations generated from Trisomy 21 iPSCs showed normal proliferative capacity and megakaryocyte production, enhanced erythropoiesis and reduced myeloid development compared to euploid iPSCs.
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Overall design |
CD41+/235+ iPSC-derived progenitor cells were flow cytometrically sorted for RNA extraction and hybridization onto Affymetrix microarrays.
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Contributor(s) |
Chou ST, Weiss MJ |
Citation(s) |
23045704 |
Submission date |
Feb 06, 2012 |
Last update date |
Jul 26, 2018 |
Contact name |
Ross Hardison |
E-mail(s) |
rch8@psu.edu
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Organization name |
Pennsylvania State University
|
Street address |
303 Wartik Lab
|
City |
University Park |
State/province |
PA |
ZIP/Postal code |
16802 |
Country |
USA |
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Platforms (1) |
GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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Samples (6)
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Relations |
BioProject |
PRJNA152683 |