|
| Status |
Public on Aug 21, 2012 |
| Title |
High throughput sequencing of the mouse transcriptome within the VTA following exposure to emotional stress. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using a novel stress paradigm, we generated emotionally stressed, physically stressed, and control animals. We measured changes in mRNA expression using Illumina HiSeq2000 to obtain high-depth sequencing. Interestingly, we observed a number of significantly up- and down-regulated mRNAs. By identifying mRNAs that were regulated similarly in both emotionally and physically stressed mice, we hope to provide a list of potentially novel targets for therapeutic intervention in mood disorder.
|
| |
|
| Overall design |
Examination of the transcriptome within the VTA in emotionally and physically (both susceptible and resilient) stressed C57BL/6J male mice.
|
| |
|
| Contributor(s) |
Warren B, Shen L, Vialou V, Bolanos-Guzman C |
| Citation(s) |
22795644 |
| Submission date |
Feb 22, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Li Shen |
| E-mail(s) |
li.shen@mssm.edu
|
| Organization name |
Icahn School of Medicine at Mount Sinai
|
| Department |
Neuroscience
|
| Lab |
Shen
|
| Street address |
1425 Madison Ave
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (12)
|
|
| Relations |
| SRA |
SRP011014 |
| BioProject |
PRJNA151701 |
Less...
More...