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| Status |
Public on May 09, 2012 |
| Title |
North American Brain Expression Consortium and UK Human Brain Expression Database: Gene Expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on mRNA expression distinct human brain regions. We show that brain tissues may be readily distinguished based on expression profile. We find an abundance of genetic cis regulation mRNA expression. We observe that the largest magnitude effects occur across distinct brain regions. We believe these data, which we have made publicly available, will be useful in understanding the biological effects of genetic variation.
Authorized Access data:
Mapping of GEO sample accessions to dbGaP subject/sample IDs is available through dbGaP Authorized Access, see http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/gap/cgi-bin/study.cgi?study_id=phs000249
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| Overall design |
Because of our interest in genomic regulation of expression and neurological disorders we embarked upon a series of experiments to provide a brain region-specific contextual framework for genetic and epigenetic regulation of gene expression. We obtained frozen brain tissue from the cerebellum and frontal cortex from 396 subjects (total 911 tissue samples).
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| Contributor(s) |
Gibbs JR, Hernandez DG, Dillman A, Ryten M, Trabzuni D, Traynor BJ, Nalls MA, Arepalli S, Ramasamy A, van der Brug MP, Troncoso J, Johnson R, O'Brien R, Zielke HR, Zonderman A, Ferrucci L, Longo DL, Smith C, Walker R, Weale M, Hardy JA, Cookson MR, Singleton AB |
| Citation(s) |
22433082, 24264146 |
| Submission date |
Mar 01, 2012 |
| Last update date |
Aug 16, 2018 |
| Contact name |
J Raphael Gibbs |
| E-mail(s) |
gibbsr@mail.nih.gov
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| Organization name |
National Institutue on Aging, NIH
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| Department |
Computational Biology Core
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| Lab |
Laboratory of Neurogenetics
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| Street address |
35 Convent Drive, Bldg 35/1A1015, MSC3707
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (911)
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| Relations |
| BioProject |
PRJNA164719 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE36192_RAW.tar |
6.2 Mb |
(http)(custom) |
TAR |
| GSE36192_non-normalized.txt.gz |
279.4 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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