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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 06, 2012 |
| Title |
Growth inhibition of ovarian tumor-initiating cells by niclosamide |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The gene expression profile in treated CP70 side population spheroid cells (CP70sps cells) was analyzed to investigate the effect of niclosamide inhibition on ovarian tumor-initiating cells. CP70sps cells are isolated and characterized as one kind of ovarian tumor-initiating cells, and they show stemness properties and drug resistance capacity. According gene expression profiles and mechanistic analysis, all evidences revealed niclosamide disrupted multiple metabolic pathways affecting biogenetics, biogenesis and redox regulation. These studies support niclosamide as a promising therapeutic agent for ovarian cancer.
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| Overall design |
CP70sps cells were treated with niclosamide for 0, 2, 4 and 6 hours respectively, and then cells were harvested and analyzed their gene expression profiles.
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| Contributor(s) |
Yo Y, Lin Y, Wang Y, Balch C, Huang R, Chan M, Sytwu H, Chen C, Chang C, Nephew KP, Huang T, Yu M, Lai H |
| Citation(s) |
22576131 |
| Submission date |
Mar 05, 2012 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Hung-Cheng Lai |
| E-mail(s) |
hclai30656@gmail.com
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| Organization name |
Taipei Medical University
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| Department |
Department of Obstetrics and Gynecology, School of Medicine, College of Medicine,
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| Street address |
No.250, Wuxing St.
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| City |
Taipei |
| ZIP/Postal code |
11031 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL6884 |
Illumina HumanWG-6 v3.0 expression beadchip |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA153081 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE36259_RAW.tar |
6.3 Mb |
(http)(custom) |
TAR |
| GSE36259_non-normalized.txt.gz |
1.4 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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