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Status |
Public on Mar 06, 2012 |
Title |
Gene expression in liver of wild-type and Dicer1-KO mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
To explore the possible changes of gene expression induced by a carcinogen, we treated wild-type and Dicer1-KO mice with one dose of 120 mg/kg N-ethyl-N-nitrosourea (ENU), a model genotoxic carcinogen, and vehicle control. The gene expression profiles were assessed in the mouse livers in wild-type and Dicer1-KO mice design. Total RNA were isolated from the livers at days 15 after the treatment and their expression was determined using Gene Array.
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Overall design |
Gene expression in treated wild-type and Dicer1-KO mice was measured at 15 days after exposure to one dose of 120 mg/kg N-ethyl-N-nitrosourea (ENU). Each treatment duplex ,Drug-ko-a,Drug-ko-b,Drug-wt-a,Drug-wt-b,Control-ko-a,Control-ko-b,Control-wt-a,Control-wt-b.
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Contributor(s) |
Yang L, Qi X, Xu L |
Citation missing |
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Submission date |
Mar 06, 2012 |
Last update date |
May 10, 2018 |
Contact name |
Luan Yang |
E-mail(s) |
yluan@cdser.simm.ac.cn
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Phone |
021-38770863
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Organization name |
Shanghai Institute of Medicine of Chinese Academy of Medical Sciences
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Street address |
555 Zu Chong Zhi Road , Zhang Jiang Hi-Tech Park, Pudong, Shanghai
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City |
shanghai |
ZIP/Postal code |
201203 |
Country |
China |
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Platforms (1) |
GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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Samples (8)
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Relations |
BioProject |
PRJNA153055 |