|
| Status |
Public on May 01, 2012 |
| Title |
Epigenetically heritable alteration of fly development in response to toxic challenge |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
|
| Summary |
Developing organisms have evolved a wide range of mechanisms for coping with recurrent environmental challenges. How they cope with rare or unforeseen challenges is, however, unclear as are the implications to their unchallenged offspring. Here we investigate these questions by confronting the development of the fly, D. melanogaster, with artificial tissue distributions of toxic stress that are not expected to occur during fly development. We show that under a wide range of toxic scenarios, this challenge can lead to modified development which may coincide with increased tolerance to an otherwise lethal condition. Part of this response was mediated by suppression of Polycomb group genes, which in turn leads to de-repression of developmental regulators and their expression in new domains. Importantly, some of the developmental alterations were epigenetically inherited by subsequent generations of unchallenged offspring. These results show that the environment can induce alternative patterns of development that are stable across multiple generations.
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| |
|
| Overall design |
Measuring differences in RNA levels between larvae that were exposed to a toxic challenge and unchallenged larvae. measuring differences in RNA levels between F3 larvae with or without past exposure to the challenge in F1 generation.
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| |
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| Citation missing |
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| Submission date |
Mar 13, 2012 |
| Last update date |
Aug 28, 2018 |
| Contact name |
Shay Stern |
| E-mail(s) |
shay.stern@weizmann.ac.il
|
| Organization name |
Weizmann Institute of Science
|
| Department |
Biological Chemistry
|
| Lab |
Soen lab
|
| Street address |
234 Herzl Street
|
| City |
Rehovot |
| ZIP/Postal code |
76100 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
|
| Samples (6)
|
| GSM894802 |
proventriculus mRNA measured from unchallenged larvae replicate 1 |
| GSM894824 |
proventriculus mRNA measured from G418 challenged larvae replicate 1 |
| GSM894896 |
proventriculus mRNA measured from unchallenged larvae replicate 2 |
| GSM894968 |
proventriculus mRNA measured from G418 challenged larvae replicate 2 |
| GSM894975 |
proventriculus mRNA measured from F3 unchallenged larvae without past exposure |
| GSM894976 |
proventriculus mRNA measured from F3 unchallenged larvae with past exposure on F1 |
|
| Relations |
| BioProject |
PRJNA156707 |
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