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| Status |
Public on Jun 30, 2012 |
| Title |
Comparative transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) isolated from patients in secondary prevention of CVD taking placebo, grape extract or resveratrol-enriched grape extract |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We used Affymetrix microarrays to investigate gene expression changes in PBMCs isolated from male patients ongoing secondary prevention of CVD to determine significant modulatory effects that may have been induced by the intake of an initial dose of 8 mg of resveratrol-enriched grape extract for 6 months and then, 16 mg for a further 6 months.
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| Overall design |
The aim of this work was to determine whether the daily intake of dietary levels of resveratrol (RES) for a total of 12 months exerted any modulatory effects, at the level of gene expression, in PBMCs isolated from patients in secondary prevention of CVD. Male patients were divided in 3 groups: placebo (A), grape extract (B) and resveratrol-enriched grape extract (C). Total RNA was extracted from isolated PBMCs belonging to a total of 18 diabetic male patients (6 from each group) in 3 time points (at day 0, after 6 months and after 12 months) to compare differential gene expression between the groups.
Differential gene expression after 6 and 12 months of the study for each group: placebo (A), grape extract (B) and resveratrol-enriched grape extract (C)
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| Contributor(s) |
García-Conesa M, Tomé-Carneiro J, Espín de Gea J |
| Citation(s) |
23557933, 23224687 |
| Submission date |
Mar 29, 2012 |
| Last update date |
Sep 17, 2019 |
| Contact name |
María-Teresa García-Conesa |
| E-mail(s) |
mtconesa@cebas.csic.es
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| Phone |
+ 34 968 396276
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| Organization name |
CEBAS-CSIC
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| Department |
Quality, Safety and Bioactivity of Plant Foods
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| Street address |
Campus de Espinardo
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| City |
Espinardo |
| State/province |
Murcia |
| ZIP/Postal code |
30100 |
| Country |
Spain |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (54)
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| GSM906467 |
Placebo group, Time 0 (basal), patient number 19 |
| GSM906468 |
Placebo group, Time 0 (basal), patient number 33 |
| GSM906469 |
Placebo group, Time 0 (basal), patient number 34 |
| GSM906470 |
Placebo group, Time 0 (basal), patient number 46 |
| GSM906471 |
Placebo group, Time 0 (basal), patient number 47 |
| GSM906472 |
Placebo group, Time 0 (basal), patient number 52 |
| GSM906473 |
Placebo group, 6 months, patient number 19 |
| GSM906474 |
Placebo group, 6 months, patient number 33 |
| GSM906475 |
Placebo group, 6 months, patient number 34 |
| GSM906476 |
Placebo group, 6 months, patient number 46 |
| GSM906477 |
Placebo group, 6 months, patient number 47 |
| GSM906478 |
Placebo group, 6 months, patient number 52 |
| GSM906479 |
Placebo group, 12 months, patient number 19 |
| GSM906480 |
Placebo group, 12 months, patient number 33 |
| GSM906481 |
Placebo group, 12 months, patient number 34 |
| GSM906482 |
Placebo group, 12 months, patient number 46 |
| GSM906483 |
Placebo group, 12 months, patient number 47 |
| GSM906484 |
Placebo group, 12 months, patient number 52 |
| GSM906485 |
Grape extract group, Time 0 (basal), patient number 11 |
| GSM906486 |
Grape extract group, Time 0 (basal), patient number 14 |
| GSM906487 |
Grape extract group, Time 0 (basal), patient number 15 |
| GSM906488 |
Grape extract group, Time 0 (basal), patient number 29 |
| GSM906489 |
Grape extract group, Time 0 (basal), patient number 32 |
| GSM906490 |
Grape extract group, Time 0 (basal), patient number 56 |
| GSM906491 |
Grape extract group, 6 months, patient number 11 |
| GSM906492 |
Grape extract group, 6 months, patient number 14 |
| GSM906493 |
Grape extract group, 6 months, patient number 15 |
| GSM906494 |
Grape extract group, 6 months, patient number 29 |
| GSM906495 |
Grape extract group, 6 months, patient number 32 |
| GSM906496 |
Grape extract group, 6 months, patient number 56 |
| GSM906497 |
Grape extract group, 12 months, patient number 11 |
| GSM906498 |
Grape extract group, 12 months, patient number 14 |
| GSM906499 |
Grape extract group, 12 months, patient number 15 |
| GSM906500 |
Grape extract group, 12 months, patient number 29 |
| GSM906501 |
Grape extract group, 12 months, patient number 32 |
| GSM906502 |
Grape extract group, 12 months, patient number 56 |
| GSM906503 |
RES-enriched Grape extract group, Time 0 (basal), patient number 13 |
| GSM906504 |
RES-enriched Grape extract group, Time 0 (basal), patient number 22 |
| GSM906505 |
RES-enriched Grape extract group, Time 0 (basal), patient number 28 |
| GSM906506 |
RES-enriched Grape extract group, Time 0 (basal), patient number 41 |
| GSM906507 |
RES-enriched Grape extract group, Time 0 (basal), patient number 51 |
| GSM906508 |
RES-enriched Grape extract group, Time 0 (basal), patient number 62 |
| GSM906509 |
RES-enriched Grape extract group, 6 months, patient number 13 |
| GSM906510 |
RES-enriched Grape extract group, 6 months, patient number 22 |
| GSM906511 |
RES-enriched Grape extract group, 6 months, patient number 28 |
| GSM906512 |
RES-enriched Grape extract group, 6 months, patient number 41 |
| GSM906513 |
RES-enriched Grape extract group, 6 months, patient number 51 |
| GSM906514 |
RES-enriched Grape extract group, 6 months, patient number 62 |
| GSM906515 |
RES-enriched Grape extract group, 12 months, patient number 13 |
| GSM906516 |
RES-enriched Grape extract group, 12 months, patient number 22 |
| GSM906517 |
RES-enriched Grape extract group, 12 months, patient number 28 |
| GSM906518 |
RES-enriched Grape extract group, 12 months, patient number 41 |
| GSM906519 |
RES-enriched Grape extract group, 12 months, patient number 51 |
| GSM906520 |
RES-enriched Grape extract group, 12 months, patient number 62 |
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| Relations |
| BioProject |
PRJNA157113 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE36930_RAW.tar |
228.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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