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Series GSE37129 Query DataSets for GSE37129
Status Public on Jul 12, 2012
Title mTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma
Organism Mus musculus
Experiment type Expression profiling by array
Summary The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial.
 
Overall design Comparative study of total RNA obtained from normal and tumor liver tissue under RAD001, BEZ235, or RAD001 + BEZ235.
 
Contributor(s) Thomas HE, Mercer CA, Carnevalli LS, Park J, Andersen JB, Conner EA, Tanaka K, Matsutani T, Iwanami A, Aronow BJ, Manway L, Maira M, Thorgeirsson SS, Mischel PS, Thomas G, Kozma SC
Citation(s) 22539746
Submission date Apr 09, 2012
Last update date Jun 14, 2018
Contact name Manway Liu
E-mail(s) manway.liu@novartis.com
Organization name Novartis Institutes for Biomedical Research
Street address 250 Massachusetts Avenue
City Cambridge
State/province MA
ZIP/Postal code 02139
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (64)
GSM911795 693liver
GSM911796 712liver
GSM911797 759liver
Relations
BioProject PRJNA158305

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37129_RAW.tar 3.1 Mb (http)(custom) TAR
GSE37129_non-normalized.txt.gz 9.7 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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