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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 12, 2012 |
| Title |
mTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial.
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| Overall design |
Comparative study of total RNA obtained from normal and tumor liver tissue under RAD001, BEZ235, or RAD001 + BEZ235.
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| Contributor(s) |
Thomas HE, Mercer CA, Carnevalli LS, Park J, Andersen JB, Conner EA, Tanaka K, Matsutani T, Iwanami A, Aronow BJ, Manway L, Maira M, Thorgeirsson SS, Mischel PS, Thomas G, Kozma SC |
| Citation(s) |
22539746 |
| Submission date |
Apr 09, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Manway Liu |
| E-mail(s) |
manway.liu@novartis.com
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| Organization name |
Novartis Institutes for Biomedical Research
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| Street address |
250 Massachusetts Avenue
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| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (64)
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| Relations |
| BioProject |
PRJNA158305 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE37129_RAW.tar |
3.1 Mb |
(http)(custom) |
TAR |
| GSE37129_non-normalized.txt.gz |
9.7 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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