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Series GSE37219 Query DataSets for GSE37219
Status Public on Aug 18, 2012
Title Comparison expression data from wild-type and NFATc1-deficient osteoclasts
Organism Mus musculus
Experiment type Expression profiling by array
Summary Genetic deletion of Nfatc1 in mice results in profound osteoclast-poor osteopetrosis, a high bone mass state caused by a lack of osteoclast activity. We hypothesized that the family of NFATc1 regulated transcripts in the osteoclast would be enriched for genes associated with osteoclast function. We used microarrays profile gene expression in wild-type and NFATc1-deficient osteoclasts generated in vitro to identify NFATc1-dependent transcripts in osteoclasts.
Overall design Bone marrow macrophages from wild-type and mice with an induced deficiency of NFATc1 (NFATc1 fl/fl MxCre+ mice where NFATc1 excision was induced by polyIC treatment) were cultured ex vivo in MCSF and RANKL for 3 days. 2 biological replicates were assayed for each genotype.
Contributor(s) Aliprantis AO
Citation(s) 18846253
Submission date Apr 12, 2012
Last update date May 04, 2018
Contact name Julia F. Charles
Organization name Brigham and Women's Hospital
Department Division of Rheumatology, Immunology and Allergy
Lab Antonios O. Aliprantis Lab
Street address 75 Francis Street, Smith Building 6th floor
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL8321 [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
Samples (4)
GSM913972 wild-type osteoclasts rep1
GSM913973 wild-type osteoclasts rep2
GSM913974 NFATc1-deficient osteoclasts rep1
BioProject PRJNA158945

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37219_RAW.tar 9.2 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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