NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE37250 Query DataSets for GSE37250
Status Public on Oct 23, 2013
Title Genome-wide transcriptional profiling of HIV positive and negative adults with active tuberculosis, latent TB infection and other diseases
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The study aimed to define transcriptional signatures for detection of active TB (TB) compared to latent TB infection (LTBI) as well as to other diseases (OD) with similar clinical phenotypes in patients with and without HIV in two African adult populations.
Transcriptional signatures were identified that distinguished active TB from LTBI, active TB from other diseases, and active TB from both LTBI and other diseases in HIV+/- patients.
 
Overall design Adults were recruited from Cape Town, South Africa (n=300) and Karonga, Malawi (n=237) who were either HIV+ or HIV - with either active TB, LTBI or OD. Blood was collected into PAX gene tubes (PreAnalytiX). Total RNA integrity was assessed using an Agilent 2100 Bioanalyzer (Agilent, Palo Alto, CA). Labeled cRNA was hybridized to Illumina Human HT-12 Beadchips. Data were analysed in R.
 
Contributor(s) Anderson ST, Coin LJ, Crampin AC, Dockrell HM, Eley B, French N, Heyderman RS, Hibberd ML, Kaforou M, Kern F, Langford PR, Levin M, Ling L, Wilkinson RJ, Wright VJ
Citation(s) 24167453
Submission date Apr 13, 2012
Last update date Nov 30, 2020
Contact name Victoria Wright
E-mail(s) v.wright@imperial.ac.uk
Organization name Imperial College London
Department Paediatrics
Lab Wright Fleming Institute
Street address Norfolk Place
City London
ZIP/Postal code W2 1PG
Country United Kingdom
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (537)
GSM914353 active tuberculosis HIV negative Malawi WB_1_M_39619
GSM914354 active tuberculosis HIV negative Malawi WB_1_M_39668
GSM914355 active tuberculosis HIV negative Malawi WB_1_M_39827
Relations
BioProject PRJNA159143

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37250_RAW.tar 26.2 Mb (http)(custom) TAR
GSE37250_non-normalized.txt.gz 152.5 Mb (ftp)(http) TXT
GSE37250_normalized.txt.gz 157.9 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap