|
| Status |
Public on Jun 02, 2014 |
| Title |
FoxA1 inhibits androgen receptor expression and suppresses prostate cancer metastasis [LNCaP, ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
FoxA1 has been shown critical for prostate development and prostate-specific gene expression regulation. In addition to its well-established role as an AR pioneering factor,several studies have recently revealed significant AR binding events in prostate cancer cells with FoxA1 knockdown. Furthermore, the role of FoxA1 itself in prostate cancer has not been carefully examined. Thus, it is important to understand the role of FoxA1 in prostate cancer and how it interacts with AR signaling. To address these questions, we generated LNCaP cells with stable FoxA1 knockdown. We performed AR/FoxA1 ChIP-seq and microarray analysis of these cells.
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| |
|
| Overall design |
ChIP_Seq examination of AR and FoxA1 binding sites in LNCaP shCtrl and shFoxA1 cells
|
| |
|
| Contributor(s) |
Jin H, Yu J |
| Citation(s) |
24875621 |
| Submission date |
Apr 17, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Hong-Jian Jin |
| E-mail(s) |
hongjian-jin@northwestern.edu
|
| Phone |
3125033041
|
| Organization name |
Northwestern University
|
| Department |
Medicine
|
| Street address |
303 E Superior St
|
| City |
Chicago |
| State/province |
IL - Illinois |
| ZIP/Postal code |
60611 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL15456 |
Illumina HiScanSQ (Homo sapiens) |
|
| Samples (9)
|
| GSM916521 |
AR_ChIP-seq_shCtrl_R1881, biological replicate 1 |
| GSM916522 |
AR_ChIP-seq_shFoxA1_R1881, biological replicate 1 |
| GSM916523 |
FoxA1_ChIP-seq_shCtrl_R1881 |
|
| This SubSeries is part of SuperSeries: |
| GSE55007 |
Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program |
|
| Relations |
| BioProject |
PRJNA159621 |
| SRA |
SRP012266 |
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