|
| Status |
Public on Nov 03, 2012 |
| Title |
Effect of small molecules on activated astrocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We have developed an assay to test the neuroprotective properties of compounds using stem cell–derived motor neurons and astrocytes, together with activated microglia as a stress paradigm.
Hit compounds were discovered and the transcriptional response on activated astrocytes cells was tested.
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| |
|
| Overall design |
Neural stem cell (NSC)-derived astrocytes (AC) were activated with LPS and IFN-γ and treated with hit compound for 4 hr.
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| |
|
| Citation(s) |
23064101 |
| Submission date |
Apr 26, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Susanne Höing |
| E-mail(s) |
s.hoeing@mpi-muenster.mpg.de
|
| Organization name |
Max Planck Institute for Molecular Biomedicine
|
| Department |
Cell and Developmental Biology
|
| Street address |
Röntgenstraße 20
|
| City |
Münster |
| ZIP/Postal code |
48149 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (12)
|
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| This SubSeries is part of SuperSeries: |
| GSE37613 |
Effect of small molecules on activated astrocytes and microglia cells |
|
| Relations |
| BioProject |
PRJNA162319 |
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