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Series GSE37722 Query DataSets for GSE37722
Status Public on Oct 15, 2012
Title Normal early pregnancy: a transient state of epigenetic change favoring hypomethylation
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary The objective of this study was to analyze genome-wide differential methylation patterns in maternal leukocyte DNA in early pregnant and non-pregnant states. This is an age- and body mass index-matched case-control study comparing the methylation patterns of 27,578 cytosine-guanine (CpG) sites in 14,495 genes in maternal leukocyte DNA in early pregnancy (n=14), in the same women postpartum (n=14), and in nulligravid women (n=14) on a BeadChip platform. Transient widespread hypomethylation was found in early pregnancy as compared with the non-pregnant states. Methylation of nine genes was significantly different in early pregnancy compared to both postpartum and nulligravid states (< 10% False Discovery Rate). Early pregnancy may be characterized by widespread hypomethylation compared to non-pregnant states; there is no apparent permanent methylation imprint after a normal-term gestation. Nine potential candidate genes were identified as differentially methylated in early pregnancy and may play a role in the maternal adaptation to pregnancy.
 
Overall design This is an age- and body mass index-matched case-control study comparing the methylation patterns of 27,578 cytosine-guanine (CpG) sites in 14,495 genes in maternal leukocyte DNA in early pregnancy (n=14), in the same women postpartum (n=14), and in nulligravid women (n=14) on a BeadChip platform.
 
Contributor(s) White WM, Brost BC, Sun Z, Rose C, Craici I, Wagner SJ, Turner S, Garovic VD
Citation(s) 22647708, 23782156
Submission date May 02, 2012
Last update date Jun 09, 2015
Contact name Zhifu Sun
Organization name Mayo Clinic
Department HSR-BSI
Street address 200 1st ST SW
City Rochester
State/province MN
ZIP/Postal code 55905
Country USA
 
Platforms (1)
GPL8490 Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)
Samples (84)
GSM926059 NL-14-Null
GSM926060 NL-1-Null
GSM926061 NL-10-Null
Relations
BioProject PRJNA162875

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37722_RAW.tar 5.8 Mb (http)(custom) TAR
GSE37722_methylated_unmethylated_signals.txt.gz 14.0 Mb (ftp)(http) TXT
Processed data included within Sample table

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