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Status |
Public on Oct 15, 2012 |
Title |
Normal early pregnancy: a transient state of epigenetic change favoring hypomethylation |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by array
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Summary |
The objective of this study was to analyze genome-wide differential methylation patterns in maternal leukocyte DNA in early pregnant and non-pregnant states. This is an age- and body mass index-matched case-control study comparing the methylation patterns of 27,578 cytosine-guanine (CpG) sites in 14,495 genes in maternal leukocyte DNA in early pregnancy (n=14), in the same women postpartum (n=14), and in nulligravid women (n=14) on a BeadChip platform. Transient widespread hypomethylation was found in early pregnancy as compared with the non-pregnant states. Methylation of nine genes was significantly different in early pregnancy compared to both postpartum and nulligravid states (< 10% False Discovery Rate). Early pregnancy may be characterized by widespread hypomethylation compared to non-pregnant states; there is no apparent permanent methylation imprint after a normal-term gestation. Nine potential candidate genes were identified as differentially methylated in early pregnancy and may play a role in the maternal adaptation to pregnancy.
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Overall design |
This is an age- and body mass index-matched case-control study comparing the methylation patterns of 27,578 cytosine-guanine (CpG) sites in 14,495 genes in maternal leukocyte DNA in early pregnancy (n=14), in the same women postpartum (n=14), and in nulligravid women (n=14) on a BeadChip platform.
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Contributor(s) |
White WM, Brost BC, Sun Z, Rose C, Craici I, Wagner SJ, Turner S, Garovic VD |
Citation(s) |
22647708, 23782156 |
Submission date |
May 02, 2012 |
Last update date |
Jun 09, 2015 |
Contact name |
Zhifu Sun |
Organization name |
Mayo Clinic
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Department |
HSR-BSI
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Street address |
200 1st ST SW
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City |
Rochester |
State/province |
MN |
ZIP/Postal code |
55905 |
Country |
USA |
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Platforms (1) |
GPL8490 |
Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2) |
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Samples (84)
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Relations |
BioProject |
PRJNA162875 |
Supplementary file |
Size |
Download |
File type/resource |
GSE37722_RAW.tar |
5.8 Mb |
(http)(custom) |
TAR |
GSE37722_methylated_unmethylated_signals.txt.gz |
14.0 Mb |
(ftp)(http) |
TXT |
Processed data included within Sample table |
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