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Status |
Public on Oct 17, 2012 |
Title |
DNA methylation profiling in breast cancer discordant identical twins |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by genome tiling array
|
Summary |
We obtained a comprehensive DNA methylation profile of 15 breast cancer discordant twins, using the high resolution Infinium HumanMethylation450 BeadChip platform (450K, Illumina), previously established to reliably detect methylation changes of more than 450,000 CpG sites. To provide insight into the temporal and causal relationships and predictive potential, samples from breast cancer patients before (7) and after diagnosis (8) were also analyzed. Using whole blood from 15 twin pairs discordant for breast cancer and high-resolution (450k) DNA methylation analysis we identified 403 differentially methylated CpG sites including known and novel potential breast cancer genes.
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Overall design |
30 Samples
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Contributor(s) |
Heyn HA, Esteller M |
Citation(s) |
23054610 |
Submission date |
May 14, 2012 |
Last update date |
Mar 22, 2019 |
Contact name |
Manel Esteller |
Organization name |
IDIBELL
|
Department |
PEBC
|
Lab |
Cancer Epigenetics
|
Street address |
Hospital Duran i Reynals Av. Gran Via s/n km, 2.7
|
City |
L'Hospitalet de Llobregat |
State/province |
Barcelona |
ZIP/Postal code |
08908 |
Country |
Spain |
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Platforms (1) |
GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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Samples (30)
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Relations |
BioProject |
PRJNA165843 |