|
| Status |
Public on Jan 22, 2013 |
| Title |
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
The results of the study uncover conserved features of cancer methylomes and provide a mechanistic explanation for the tumor-promoting effects of Dnmt3a mutations.
|
| |
|
| Overall design |
Whole genome methylation analysis of Mus musculus. Five samples were analyzed, one control sample containing normal healthy lung tissue, two samples containing big (WTB) or small (WTS) Dnmt3a WT tumors, two samples containing big (KOB) or small (KOS) Dnmt3a knock-out tumors
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| |
|
| Contributor(s) |
Lyko F, Jaenisch R |
| Citation(s) |
23284304 |
| Submission date |
Jun 12, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Guenter Raddatz |
| Organization name |
German Center for Cancer Research
|
| Street address |
Im Neuenheimer Feld 580
|
| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (5)
|
| GSM946855 |
Healthy lung tissue |
| GSM946856 |
Big lung tumor tissue with Dnmt3a knocked out |
| GSM946857 |
Small lung tumor tissue with Dnmt3a knocked out |
| GSM946858 |
Big lung tumor tissue with Dnmt3a intact |
| GSM946859 |
Small lung tumor tissue with Dnmt3a intact |
|
| Relations |
| SRA |
SRP013702 |
| BioProject |
PRJNA168371 |
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