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Series GSE38688 Query DataSets for GSE38688
Status Public on Feb 27, 2013
Title Systems biology analysis unravels complementary action of combined Rosuvastatin and Ezetimibe therapy
Organism Mus musculus
Experiment type Expression profiling by array
Summary Transcriptomics analysis to understand both efficacy and side effects of a cholesterol lowering drug combination therapy based on biological pathways and molecular processes affected by each drug alone or in combination. We have treated ApoE*3Leiden mice, a humanized atherosclerosis model with a unique human-like response to cholesterol-lowering drugs, with RSV and EZE alone and in combination. We demonstrate that processes affected by monotherapy can be retained and enhanced by combination therapy. In addition, combination therapy also affects a number of processes which are not predictable on basis of monotherapy – at least when analysis is performed within the borders of statistical significance. Our data however provide clues for these “non-predictable” effects.
 
Overall design Total RNA obtained from mouse liver from mice treated with High-Cholesterol (HC) diet as control (n=8) or HC+RSV (n=8) or HC+EZE (n=8) or HC+RSV+EZE (n=8).
 
Contributor(s) Verschuren L, Radonjic M, Wielinga PY, Kelder T, Kooistra T, van Ommen B, Kleemann R
Citation(s) 23086299
Submission date Jun 13, 2012
Last update date Jun 14, 2018
Contact name Lars Verschuren
E-mail(s) lars.verschuren@tno.nl
Phone +31888666039
Organization name TNO
Department Microbiology and Systems Biology
Street address Utrechtseweg 48
City Zeist
ZIP/Postal code 3704HE
Country Netherlands
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (32)
GSM947552 High cholesterol diet HC rep1
GSM947553 High cholesterol diet HC rep2
GSM947554 High cholesterol diet HC rep3
Relations
BioProject PRJNA168440

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38688_RAW.tar 3.1 Mb (http)(custom) TAR
GSE38688_non-normalized.txt.gz 2.9 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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