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| Status |
Public on Jan 01, 2015 |
| Title |
Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To increase our understanding of the mechanisms that underlie neuroprotection following glutamate receptor-induced excitotoxicity, we treated primary CD-1 mouse cortical neurons with NMDA in the presence of absence of neuroprotective compounds. The results indicate a convergence at the level of whole genome expression, despite the divergent chemistries and purported mechanisms of action.
While more arrays were performed than published, only the extreme arrays were used in subsequent analyses.
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| Overall design |
CD-1 Mouse cortical neurons were exposed to NMDA, in the presence or absence of neuroprotective molecules, followed by a recovery period (16hr) and total RNA extraction.
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| Contributor(s) |
Pappas DJ |
| Citation(s) |
22986168 |
| Submission date |
Jun 13, 2012 |
| Last update date |
Mar 30, 2015 |
| Contact name |
Derek Pappas |
| E-mail(s) |
djpappas75@gmail.com
|
| Organization name |
University of California, San Francisco
|
| Department |
Neurology
|
| Lab |
Jorge Oksenberg
|
| Street address |
675 Nelson Rising Lane, RM 240
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
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| Platforms (1) |
| GPL6105 |
Illumina mouse-6 v1.1 expression beadchip |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA168448 |
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