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Series GSE38964 Query DataSets for GSE38964
Status Public on Feb 28, 2013
Title Identification of eight candidate target genes of the prognsotic 3p loss in cervical cancer by integrative genomic profiling
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We performed integrative gene dosage and expression profiling to identify candidate target genes of the prognostic 3p loss in cervical cancer.
Candidate target genes were proposed from the correlation between gene dosage and gene expression. Combined network, gene set, and gene ontology analysis of the gene expression profiles depicted interaction partners of the candidate targets and proposed biological processes that were affected by the 3p loss.
 
Overall design Gene dosages from array CGH data (previously submiited to ArrayExpress) were correlated with Illumina gene expression data in the integrative patient cohort. The prognostic significance of the candidate target genes was validated based on the Illumina gene expression data of the validation cohort. Changes in gene expressions after knockdown of three candidate targets, RYBP, TMF1 and PSMD6, were studied by Illumina beadarrays in the cervical cancer cell lines HeLa, SiHa and CaSki.
 
Contributor(s) Lando M, Snipstad K, Lando M, Clancy T, Bierkens M, Holden M, Stokke T, Sundfør K, Holm R, Kristensen GB, Steenbergen RD, Lyng H
Citation(s) 23335387
Submission date Jun 27, 2012
Last update date Jun 24, 2020
Contact name Heidi Lyng
E-mail(s) heidi.lyng@rr-research.no
Phone 4722781478
Organization name Oslo University Hospital
Department Department of Radiation Biology
Street address Montebello
City Oslo
ZIP/Postal code 0310
Country Norway
 
Platforms (2)
GPL6884 Illumina HumanWG-6 v3.0 expression beadchip
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (164)
GSM678702 Cervical tumor biopsy, P-002
GSM678703 Cervical tumor biopsy, P-004
GSM678704 Cervical tumor biopsy, P-005
Relations
BioProject PRJNA170108

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38964_RAW.tar 32.4 Mb (http)(custom) TAR
GSE38964_non_normalized_151Patients.txt.gz 45.4 Mb (ftp)(http) TXT
GSE38964_non_normalized_CaSki_SiHa.txt.gz 2.8 Mb (ftp)(http) TXT
GSE38964_non_normalized_HeLa.txt.gz 1.4 Mb (ftp)(http) TXT
Processed data included within Sample table
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