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Series GSE39029 Query DataSets for GSE39029
Status Public on Apr 23, 2013
Title Choriodecidual Infection Downregulates Angiogenesis and Morphogenesis Pathways in Fetal Lungs from Macaca Nemestrina
Platform organism Macaca mulatta
Sample organism Macaca nemestrina
Experiment type Expression profiling by array
Summary Intrauterine exposure to amniotic fluid (AF) cytokines is thought to predispose to bronchopulmonary dysplasia (BPD). We evaluated the effects of GBS exposure on RNA expression in fetal lung tissue to determine early molecular pathways associated with fetal lung injury that may progress to BPD.
 
Overall design Ten chronically catheterized pregnant monkeys (Macaca nemestrina) at 118-125 days gestation (term=172 days) received choriodecidual inoculation of either: 1) Group B Streptococcus (n=5) or 2) saline (n=5). Cesarean section and fetal necropsy was performed in the first week after GBS or saline inoculation regardless of labor. RNA was extracted from fetal lungs and profiled by microarray. Results were analyzed using single gene, Gene Set, and Ingenuity Pathway Analysis. Validation was by RT-PCR and immunohistochemistry.
 
Contributor(s) Bammler TK, Beyer RP, McAdams RM, Vanderhoeven J, Farin FM, Gravett MG, Rubens CE, Adams-Waldorf KM
Citation(s) 23056493
Submission date Jun 29, 2012
Last update date Sep 05, 2017
Contact name James William MacDonald
E-mail(s) jmacdon@uw.edu
Organization name University of Washington
Department Environmental and Occupational Health Sciences
Street address 4225 Roosevelt Way NE
City Seattle
State/province WA
ZIP/Postal code 98105-6099
Country USA
 
Platforms (1)
GPL3535 [Rhesus] Affymetrix Rhesus Macaque Genome Array
Samples (10)
GSM954238 SalineControl_M05267
GSM954239 SalineControl_5109
GSM954240 SalineControl_4105
Relations
BioProject PRJNA169645

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39029_RAW.tar 41.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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