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Series GSE39062 Query DataSets for GSE39062
Status Public on Jul 03, 2013
Title Genome-wide expression profiling analysis of a Hmgn1, 3 and 5 mutant mouse model
Organism Mus musculus
Experiment type Expression profiling by array
Summary Members of the HMGN protein family bind to nucleosomes and affect chromatin structure and functions as transcription, replication and DNA repair as well as epigenetic modifications. Overexpression of Hmgn1 may be linked to the etiology of Down syndrome while underexpression may be linked to some leukemias. Hmgn3 is highly expressed in eye and in brain and might influence behavioral phenotype. For Hmgn5 effects on transcription levels e.g. in liver are suggested.
 
Overall design Total RNA obtained from four homozygote mutant and wildtype male mice were compared.
 
Contributor(s) Beckers J, Horsch M
Citation(s) 23620591
Submission date Jul 02, 2012
Last update date Jun 14, 2018
Contact name Martin Irmler
Organization name Helmholtz Zentrum M√ľnchen GmbH
Department Institute of Experimental Genetics
Lab Gene Regulation & Epigenetics
Street address Ingolstaedter Landstrasse 1
City Neuherberg
State/province Bayern
ZIP/Postal code 85764
Country Germany
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (94)
GSM954875 30180624_brain_wt_rep1
GSM954876 30180621_brain_wt_rep2
GSM954877 30180622_brain_wt_rep3
Relations
BioProject PRJNA169857

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39062_RAW.tar 3.1 Mb (http)(custom) TAR
GSE39062_non_normalized.txt.gz 14.2 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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