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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 21, 2012 |
| Title |
Early immunologic events at the tick-host interface |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Ixodes species ticks are competent vectors of tick-borne viruses including tick-borne encephalitis and Powassan encephalitis. Tick saliva has been shown to facilitate and enhance viral infection. This likely occurs by saliva-mediated modulation of host responses into patterns favorable for viral infection and dissemination. Because of the rapid kinetics of tick-borne viral transmission, this modulation must occur as early as tick attachment and initiation of feeding. In this study, the gene expression profile of cutaneous bite-site lesions created by uninfected ticks were analyzed at 1, 3, 6, and 12 hours after Ixodes scapularis nymphal tick attachment to discover host pathways or responses potentially important in tick-borne viral establishment.
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| Overall design |
Four milimeter ear biopsies from BALB/cJ mice infested with Ixodes scapularis nymphs were assayed using Affymetrix genechip 430A 2.0 arrays at 1, 3, 6, and 12 hours after infestation during a primary exposure. 3 mice were measured at each time point. Controls were 3 similarly housed but tick-free mice.
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| Contributor(s) |
Heinze DM, Carmical JR, Aronson JF, Thangamani S |
| Citation(s) |
23077588 |
| Submission date |
Jul 04, 2012 |
| Last update date |
May 04, 2018 |
| Contact name |
Dar Heinze |
| E-mail(s) |
daheinze@utmb.edu
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| Organization name |
University of Texas Medical Branch
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| Department |
Pathology
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| Street address |
301 University Blvd
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| City |
Galveston |
| State/province |
Texas |
| ZIP/Postal code |
77555 |
| Country |
USA |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (15)
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| GSM956139 |
Tick-infested mouse, 1 hour after tick attachment, biological rep1 |
| GSM956140 |
Tick-infested mouse, 1 hour after tick attachment, biological rep2 |
| GSM956141 |
Tick-infested mouse, 1 hour after tick attachment, biological rep3 |
| GSM956142 |
Tick-infested mouse, 3 hour after tick attachment, biological rep1 |
| GSM956143 |
Tick-infested mouse, 3 hour after tick attachment, biological rep2 |
| GSM956144 |
Tick-infested mouse, 3 hour after tick attachment, biological rep3 |
| GSM956145 |
Tick-infested mouse, 6 hour after tick attachment, biological rep1 |
| GSM956146 |
Tick-infested mouse, 6 hour after tick attachment, biological rep2 |
| GSM956147 |
Tick-infested mouse, 6 hour after tick attachment, biological rep3 |
| GSM956148 |
Tick-infested mouse, 12 hour after tick attachment, biological rep1 |
| GSM956149 |
Tick-infested mouse, 12 hour after tick attachment, biological rep2 |
| GSM956150 |
Tick-infested mouse, 12 hour after tick attachment, biological rep3 |
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| Relations |
| BioProject |
PRJNA170055 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE39100_RAW.tar |
29.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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