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| Status |
Public on Sep 15, 2012 |
| Title |
Effect of ATF4 gene knockout on skeletal muscle mRNA levels in fasted mice. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
ATF4 is a fasting-induced trascription factor that promotes skeletal muscle atrophy. The goal of these studies was to determine how of loss of ATF4 affects skeletal muscle mRNA expression.
For additional details see Ebert et al, Stress-Induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy. JBC epub. June 12, 2012.
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| Overall design |
Muscle-specfic ATF4 knockout (ATF4 mKO) mice and littermate controls were fasted for 24 hours and then tibialis anterior muscles were harvested. mRNA levels in ATF4 mKO muscles were normalized to levels in littermate control muscles.
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| Contributor(s) |
Ebert SM, Adams CM |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 09, 2012 |
| Last update date |
Mar 06, 2018 |
| Contact name |
Christopher Adams |
| Organization name |
University of Iowa
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| Street address |
540G EMRB, 200 Hawkins Drive
|
| City |
Iowa City |
| State/province |
IA |
| ZIP/Postal code |
52242 |
| Country |
USA |
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| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA170206 |
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