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| Status |
Public on Jul 11, 2012 |
| Title |
Modulation of mucosal immune responses to Clostridium difficile by peroxisome proliferator-activated receptor γ and microRNA-146b |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
BACKGROUND: miRNA have been shown to play an important role during immune-mediated diseases such as inflammatory bowel disease. The aim of this study was to assess differential expression of miRNA between uninfected and infected mice with Clostridium difficile strain VPI 10463
RESULTS: MicroRNA (miRNA)-sequencing analysis indicated that miR-146b, miR-1940, and miR-1298 were significantly overexpressed in colons of C. difficile-infected mice
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| Overall design |
Colon of uninfected and C.difficile-infected C57BL6/J WT mice were sampled at day 4 post-infection with Clostridium difficile VPI 10463. The infection dose was 107 cfu/mouse.
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| Contributor(s) |
Michalak P, Bassaganya-Riera J, Hontecillas R, Viladomiu M |
| Citation(s) |
23071818 |
| Submission date |
Jul 10, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Pawel Michalak |
| E-mail(s) |
pawel@vbi.vt.edu
|
| Phone |
5402313489
|
| Fax |
5402313489
|
| Organization name |
Virginia Bioinformatics Institute
|
| Street address |
MC 0477
|
| City |
Blacksburg |
| State/province |
VA |
| ZIP/Postal code |
24061 |
| Country |
USA |
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| Platforms (1) |
| GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA170259 |
| SRA |
SRP014184 |
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