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Series GSE39313 Query DataSets for GSE39313
Status Public on Oct 18, 2012
Title The role of FGF21 in aging and aging-related diseases
Organism Mus musculus
Experiment type Expression profiling by array
Summary Aging and aging-related diseases represent an increasing burden on modern society. Thus, drugs that retard the aging process are highly desirable. Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces hepatic fatty acid oxidation and ketogenesis, increases insulin sensitivity and blocks somatic growth. Here we show that transgenic overexpression of FGF21 markedly extends lifespan in mice without reducing food intake or affecting AMP kinase or mTOR signaling or NAD metabolism. Transcriptomic analysis suggests that FGF21 acts primarily by blunting the growth hormone/insulin-like growth factor-1 signaling pathway in liver. These findings raise the possibility that FGF21 can be used as a hormone therapy to extend lifespan.
Overall design Liver, epididymal fat and gastrocnemius muscle RNA expression profiles were compared between C57Bl/6J ad libitum, fasted, and calorically restricted mice, as well as between FGF-21 transgenic and their wild-type C57Bl/6J controls.
Contributor(s) Yu RT, Zhang Y, Kliewer SA
Citation(s) 23066506
Submission date Jul 12, 2012
Last update date Jun 14, 2018
Contact name Ruth T Yu
Organization name Salk Institute
Department Gene Expression Lab
Lab Ronald Evans
Street address 10010 N Torrey Pines Rd
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (48)
GSM960682 WT AL Liver biological replicate 1
GSM960683 WT AL Liver biological replicate 2
GSM960684 WT AL Liver biological replicate 3
BioProject PRJNA170543

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39313_RAW.tar 3.1 Mb (http)(custom) TAR
GSE39313_non-normalized.txt.gz 7.4 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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