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Series GSE39345 Query DataSets for GSE39345
Status Public on Aug 01, 2012
Title Microarray gene expression profiles of peripheral blood mononuclear cells in patients with advanced stage non-small cell lung cancer treated with first line combination chemotherapy
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We have extended our investigation to advanced-stage NSCLC by analyzing gene expression in peripheral blood mononuclear cells (PBMC) from patients with newly-diagnosed NSCLC and histopathology of either AC or SCC. Furthermore, to establish a direct link between gene expression and chemotherapy treatment, PBMC from patients who have received 4 courses of combination chemotherapy with CDDP and GEM were obtained, and the effects of chemotherapy on global gene expression were evaluated using microarray analyses.
 
Overall design We analyzed microarray gene expression profiles of peripheral blood mononuclear cells from 30 patients with newly-diagnosed advanced stage NSCLC, and 20 age, sex, and co-morbidity-matched healthy controls (HC). All the cancer patients received a maximum of six courses of chemotherapy with cisplatin and gemcitabine of a 28-day cycle as first line treatment.Furthermore, to establish a direct link between gene expression and chemotherapy treatment, PBMC from patients who have received 4 courses of combination chemotherapy with CDDP and GEM were obtained, and the effects of chemotherapy on global gene expression were evaluated using microarray analyses.
 
Contributor(s) Chen Y, Chen K
Citation(s) 23451142
Submission date Jul 13, 2012
Last update date Oct 10, 2017
Contact name yungche chen
E-mail(s) tlm8570@gmail.com
Organization name Kaohsiung Chang Gung Memorial Hospital
Street address 123, Ta-Pei Rd. Niao-Sung Dist.
City Kaohsiung
ZIP/Postal code 833
Country Taiwan
 
Platforms (1)
GPL6104 Illumina humanRef-8 v2.0 expression beadchip
Samples (69)
GSM966355 lung cancer patient before chemotherapy-01
GSM966356 lung cancer patient before chemotherapy-02
GSM966357 lung cancer patient before chemotherapy-03
Relations
BioProject PRJNA170740

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39345_RAW.tar 3.4 Mb (http)(custom) TAR
GSE39345_non-normalized.txt.gz 17.4 Mb (ftp)(http) TXT
Processed data included within Sample table

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