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| Status |
Public on Jul 17, 2012 |
| Title |
Discordant cellular response to pre-surgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
This clinical case resulted from an ongoing trial at Vanderbilt University and abroad where ER+ breast cancer patients are administered 2-3 weeks of aromatase inhibitor therapy leading up to definitive surgical resection of the tumor. In this case, we describe a study patient presenting with bilateral primary ER+ breast tumors. Short term hormonal therapy substantially reduced proliferation in one tumor, while the second was essentially unchanged. Extensive molecular and genetic workup of the two tumors yielded divergent lesions in the two tumors; an activating KRAS mutation in the responsive tumor, and an amplification of the FGFR1 locus in the treatment-refractory tumor.
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| Overall design |
Surgical tumor specimens from ER+ breast cancer patient 7603 who was administered letrozole for 16 days leading up to definitive surgery were utilized for RNA extraction and hybridization to Affymetrix Gene expression microarrays.
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| Contributor(s) |
Balko JM, Arteaga CL |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 16, 2012 |
| Last update date |
Apr 20, 2018 |
| Contact name |
Justin M Balko |
| Organization name |
Vanderbilt University
|
| Department |
Medicine
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| Lab |
Arteaga
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| Street address |
777 Preston Research Building
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| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37232-6307 |
| Country |
USA |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA170759 |
