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Series GSE39549 Query DataSets for GSE39549
Status Public on Mar 01, 2014
Title Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity
Organism Mus musculus
Experiment type Expression profiling by array
Summary Time-course analysis of adipocyte gene expression profiles response to high fat diet. The hypothesis tested in the present study was that in diet-induced obesity, early activation of TLR-mediated inflammatory signaling cascades by CD antigen genes, leads to increased expression of pro-inflammatory cytokines and chemokines, resulting in chronic low-grade inflammation. Early changes in collagen genes may trigger the accumulation of ECM components, promoting fibrosis in the later stages of diet-induced obesity. New therapeutic approaches targeting visceral adipose tissue genes altered early by HFD feeding may help ameliorate the deleterious effects of a diet-induced obesity.
 
Overall design Total RNA obtained from isolated epididymal and mesenteric adipose tissue of C57BL/6J mice fed normal diet or high fat diet for 2, 4, 8, 20 and 24weeks
 
Contributor(s) Kwon E, Choi M
Citation(s) 22947075, 21618427
Submission date Jul 21, 2012
Last update date Jan 16, 2019
Contact name Myung-Sook Choi
E-mail(s) mschoi@knu.ac.kr
Phone 821085881950
Organization name Kyungpook National University
Department Food and Nutrition
Lab Nutrigenomics
Street address 1370, Sankyuk-Dong, Buk-gu
City Daegu
ZIP/Postal code 702-701
Country South Korea
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (91)
GSM971546 Mice fed Normal diet for 2weeks rep1
GSM971547 Mice fed Normal diet for 2weeks rep2
GSM971548 Mice fed Normal diet for 2weeks rep3
Relations
BioProject PRJNA171109

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39549_Matrix_non-normalized_EPI.txt.gz 8.4 Mb (ftp)(http) TXT
GSE39549_Matrix_non-normalized_MES.txt.gz 2.9 Mb (ftp)(http) TXT
GSE39549_RAW.tar 15.8 Mb (http)(custom) TAR
Raw data are available on Series record
Processed data included within Sample table

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