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| Status |
Public on Sep 12, 2012 |
| Title |
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Extra chromosome copies markedly alter the physiology of eukaryotic cells, but the underlying reasons are not well understood. We created human trisomic and tetrasomic cell lines and determined the quantitative changes in their genome, transcriptome and proteome in comparison to their diploid counterparts.
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| |
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| Overall design |
Aneuploid cell lines derived from HCT116 and RPE-1 cell lines were compared to their diploid counterparts; per study, 3 biological replicates have been performed.
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| |
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| Contributor(s) |
Silvia C, Gabriele S, Zuzana S |
| Citation(s) |
22968442, 25205676 |
| Submission date |
Jul 31, 2012 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Gabriele Stoehr |
| Organization name |
MPI of Biochemistry
|
| Department |
Proteomics ans Signaltransduction
|
| Street address |
Am Klopferspitz 18
|
| City |
Martinsried |
| ZIP/Postal code |
82152 |
| Country |
Germany |
| |
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| Platforms (2) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA171695 |
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