|
| Status |
Public on Jan 15, 2013 |
| Title |
Hypoxia induces myocardial regeneration in zebrafish |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by array
|
| Summary |
Conditional expression of dominant-negative HIF1a in zebrafish cardiomyocytes severely inhibits heart regeneration. To understand more about the mechanism, we performed microarray analysis of wildtype regenerating zebrafish and dnHIF1a regenerating zebrafish to determine which genes are regulated by hypoxia/HIF1a.
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| |
|
| Overall design |
We amputated both wildtype and dnHIF1a zebrafish and allowed them to regenerate for 7 days, then compared their transcriptomic profile with unamputated wildtype and dnHIF1a zebrafish, respectively.
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| |
|
| Contributor(s) |
Ispizua Belmonte JC, Jopling C |
| Citation(s) |
23151342 |
| Submission date |
Aug 02, 2012 |
| Last update date |
Jan 25, 2018 |
| Contact name |
Chris Jopling |
| E-mail(s) |
chris.jopling@igf.cnrs.fr
|
| Phone |
+33 434359253
|
| Organization name |
Institut de Génomique Fonctionnelle
|
| Department |
Physiologie
|
| Lab |
Molecular mechansims of regeneration
|
| Street address |
141 rue de la Cardonille
|
| City |
Montpellier |
| ZIP/Postal code |
34094 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL1319 |
[Zebrafish] Affymetrix Zebrafish Genome Array |
|
| Samples (12)
|
| GSM980273 |
Unamputated dnHIF1a-expressing adult zebrafish, sample 1 |
| GSM980274 |
Unamputated dnHIF1a-expressing adult zebrafish, sample 2 |
| GSM980275 |
Unamputated dnHIF1a-expressing adult zebrafish, sample 3 |
| GSM980276 |
Unamputated wildtype adult zebrafish, sample 1 |
| GSM980277 |
Unamputated wildtype adult zebrafish, sample 2 |
| GSM980278 |
Unamputated wildtype adult zebrafish, sample 3 |
| GSM980279 |
7 days post-amputation dnHIF1a-expressing adult zebrafish, sample 1 |
| GSM980280 |
7 days post-amputation dnHIF1a-expressing adult zebrafish, sample 2 |
| GSM980281 |
7 days post-amputation dnHIF1a-expressing adult zebrafish, sample 3 |
| GSM980282 |
7 days post-amputation wildtype adult zebrafish, sample 1 |
| GSM980283 |
7 days post-amputation wildtype adult zebrafish, sample 2 |
| GSM980284 |
7 days post-amputation wildtype adult zebrafish, sample 3 |
|
| Relations |
| BioProject |
PRJNA171838 |
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