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Series GSE40085 Query DataSets for GSE40085
Status Public on Dec 22, 2015
Title Expression data from Amacr knock-out mouse liver
Organism Mus musculus
Experiment type Expression profiling by array
Summary Bile acids play multiple roles in vertebrate metabolism by facilitating lipid absorption in the intestine and acting as a signaling molecule in lipid and carbohydrate metabolism. Bile acids are also the main route to excrete excess cholesterol out of the body. Alpha-methyl-Coa racemase (Amacr) is one of the enzymes needed to produce bile acids from cholesterol. The mouse model lacking Amacr can produce only minor (less than 10%) amounts of bile acids, but still they are symptomless in normal laboratory conditions.
 
Overall design Bile acid synthesis occurs in liver. In this experiment, liver samples from Amacr-/- and wild-type mice were collected and their gene expression levels were compared. 4 biological replicates per genotype.
 
Contributor(s) Autio KJ, Kvist AP
Citation(s) 26248199
Submission date Aug 13, 2012
Last update date Dec 22, 2015
Contact name Kaija J Autio
E-mail(s) kaija.autio@oulu.fi
Phone +358 294 48 1142
Organization name University of Oulu
Department Faculty of Biochemistry and Molecular Medicine
Street address P.O.Box 5400
City University of Oulu
ZIP/Postal code 90014
Country Finland
 
Platforms (1)
GPL14661 [Mouse430_2_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 13]
Samples (8)
GSM984783 wild-type mouse liver, biological rep1
GSM984784 wild-type mouse liver, biological rep2
GSM984785 wild-type mouse liver, biological rep3
This SubSeries is part of SuperSeries:
GSE40125 Expression data from Amacr knock-out mouse liver and intestine
Relations
BioProject PRJNA172865

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40085_RAW.tar 29.7 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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