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Series GSE4017 Query DataSets for GSE4017
Status Public on Jan 12, 2006
Title DNA copy number changes in prostate cancer cell lines
Organism Homo sapiens
Experiment type Genome variation profiling by array
Summary Abstract: BACKGROUND: The aim of this study was to characterize gene expression and DNA copy number profiles in androgen sensitive (AS) and androgen insensitive (AI) prostate cancer cell lines on a genome-wide scale. METHODS: Gene expression profiles and DNA copy number changes were examined using DNA microarrays in eight commonly used prostate cancer cell lines. Chromosomal regions with DNA copy number changes were identified using cluster along chromosome (CLAC). RESULTS: There were discrete differences in gene expression patterns between AS and AI cells that were not limited to androgen-responsive genes. AI cells displayed more DNA copy number changes, especially amplifications, than AS cells. The gene expression profiles of cell lines showed limited similarities to prostate tumors harvested at surgery. CONCLUSIONS: AS and AI cell lines are different in their transcriptional programs and degree of DNA copy number alterations. This dataset provides a context for the use of prostate cancer cell lines as models for clinical cancers.
Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc.
Keywords: Logical Set
 
Overall design Computed
Web link http://www.stanford.edu/~hongjuan/prostate%20cell%20line/
 
Contributor(s) Zhao H
Citation(s) 15486987
Submission date Jan 11, 2006
Last update date Mar 17, 2012
Organization Stanford Microarray Database (SMD)
E-mail(s) array@genome.stanford.edu
Phone 650-498-6012
URL http://genome-www5.stanford.edu/
Department Stanford University, School of Medicine
Street address 300 Pasteur Drive
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
 
Platforms (1)
GPL3355 SHDJ
Samples (8)
GSM91924 DU145vsXY
GSM91925 MDA2AvsXY
GSM91926 22Rv1vsXY
This SubSeries is part of SuperSeries:
GSE4396 Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines
Relations
BioProject PRJNA104595

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Supplementary data files not provided

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