|
| Status |
Public on Dec 01, 2012 |
| Title |
Constitutional Trisomy 8 Mosaicism as a Model for Epigenetic Studies of Aneuploidy (microRNA) |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
To increase our understanding of epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient.
We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.
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| |
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| Overall design |
comparison of trisomy 8 cells with disomic as well as reference fibroblasts
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| |
|
| Contributor(s) |
Davidsson J, Johansson B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 23, 2012 |
| Last update date |
May 02, 2017 |
| Contact name |
Josef Davidsson |
| E-mail(s) |
josef.davidsson@med.lu.se
|
| Organization name |
Lund University
|
| Department |
Clinical Genetics
|
| Street address |
BMC B13
|
| City |
Lund |
| ZIP/Postal code |
22185 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL8786 |
[miRNA-1] Affymetrix Multispecies miRNA-1 Array |
|
| Samples (10)
|
| GSM991266 |
47,XY,+8 4 miRNA |
| GSM991267 |
47,XY,+8 5 miRNA |
| GSM991268 |
47,XY,+8 6 miRNA |
| GSM991269 |
46,XX 7 miRNA |
| GSM991270 |
46,XY 8 miRNA |
| GSM991271 |
46,XX 1lt miRNA |
| GSM991272 |
46,XY 6lt miRNA |
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| This SubSeries is part of SuperSeries: |
| GSE40321 |
Constitutional Trisomy 8 Mosaicism as a Model for Epigenetic Studies of Aneuploidy |
|
| Relations |
| BioProject |
PRJNA173494 |
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