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Series GSE40341 Query DataSets for GSE40341
Status Public on Aug 28, 2012
Title Effect of Chlorpromazine HCl on Rat Primary Hepatocytes.
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary This study provides an evaluation of changes in gene expression associated with chlorpromazine HCl treatment of rat hepatocytes in vitro.
Primary rat hepatocytes were treated for 24 and 48 hours with two doses (0.8 uM and 20 uM) of chlorpromazine HCl and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.
 
Overall design This series is part of a SuperSeries in which primary rat hepatocytes were treated with two doses of ten chemical compounds (and corresponding vehicle controls) for 24 and 48 hours. Each compound/vehicle treatment group was an individual study performed at different times. Each study was analyzed separately and themes common between studies were reported.
Time Course/Dose Response
 
Contributor(s) Tiesman JP
Citation(s) 25475144
Submission date Aug 23, 2012
Last update date Jul 31, 2017
Contact name Jay Patrick Tiesman
Organization name Procter & Gamble
Department Global Biotechnology
Lab Mason Business Center
Street address PO BOX 8006
City MASON
State/province OH
ZIP/Postal code 45040-8006
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (30)
GSM991599 Chlorpromazine HCl 24hr 1% DMSO GSS0190_Overmann_Rat_VII_01_1806-006
GSM991600 Chlorpromazine HCl 24hr 0.8 uM GSS0190_Overmann_Rat_VII_02_1806-006
GSM991601 Chlorpromazine HCl 24hr 20 uM GSS0190_Overmann_Rat_VII_03_1806-006
This SubSeries is part of SuperSeries:
GSE40348 Hepatotoxicity
Relations
BioProject PRJNA173836

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40341_RAW.tar 80.5 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
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