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Series GSE40346 Query DataSets for GSE40346
Status Public on Aug 28, 2012
Title Effect of WY-14643 on Rat Primary Hepatocytes.
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary This study provides an evaluation of changes in gene expression associated with WY-14643 treatment of rat hepatocytes in vitro.
Primary rat hepatocytes were treated for 24 and 48 hours with two doses 8 uM and 200 uM) of WY-14643 and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.
 
Overall design This series is part of a SuperSeries in which primary rat hepatocytes were treated with two doses of ten chemical compounds (and corresponding vehicle controls) for 24 and 48 hours. Each compound/vehicle treatment group was an individual study performed at different times. Each study was analyzed separately and themes common between studies were reported.
Time Course/Dose Response
 
Contributor(s) Tiesman JP
Citation(s) 25475144
Submission date Aug 23, 2012
Last update date Jul 31, 2017
Contact name Jay Patrick Tiesman
Organization name Procter & Gamble
Department Global Biotechnology
Lab Mason Business Center
Street address PO BOX 8006
City MASON
State/province OH
ZIP/Postal code 45040-8006
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (30)
GSM991727 WY-14643 24hr 1% DMSO GSS0214_Overmann_X_01_1806-031
GSM991728 WY-14643 24hr 8 uM GSS0214_Overmann_X_02_1806-031
GSM991729 WY-14643 24hr 200 uM GSS0214_Overmann_X_03_1806-031
This SubSeries is part of SuperSeries:
GSE40348 Hepatotoxicity
Relations
BioProject PRJNA173839

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40346_RAW.tar 84.2 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
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