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| Status |
Public on Sep 12, 2012 |
| Title |
IM010 - Infection with A/Vietnam/1203/04 H5N1 influenza virus of C57BL/6J mice, IDO1 KO mice or TNFRSF1B KO mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Comparison of the host response to VN1203 infection in three different strains of mice: Wild-type C57BL/6J mice, IDO1 KO mice and TNFRSF1B KO.
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| Overall design |
Groups of 6-week-old mice were infected with A/Vietnam/1203/04 H5N1 influenza virus at a dose of 10^3 PFU or mock infected. Mice were euthanized on days 2 and 6 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.
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| Contributor(s) |
Kawaoka Y, Katze M, Eisfeld A, Law L, Chang J, Li C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 11, 2012 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Michael Katze |
| E-mail(s) |
data@viromics.washington.edu
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| Organization name |
University of Washington
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| Department |
Microbiology
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| Lab |
Michael G. Katze, Ph.D
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| Street address |
Rosen Building 960 Republican St.
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109-4325 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA174988 |
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