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| Status |
Public on Sep 13, 2012 |
| Title |
SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice.
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| Overall design |
Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.
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| Contributor(s) |
Baric R, Katze M, Gralinski L, Law L, Chang J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 12, 2012 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Michael Katze |
| E-mail(s) |
data@viromics.washington.edu
|
| Organization name |
University of Washington
|
| Department |
Microbiology
|
| Lab |
Michael G. Katze, Ph.D
|
| Street address |
Rosen Building 960 Republican St.
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109-4325 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA175064 |
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