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| Status |
Public on Jul 03, 2013 |
| Title |
Gene expression in mouse retinas with cone cyclic nucleotide gated channel deficiencies |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The cone photoreceptor cyclic nucleotide-gated (CNG) channel is essential for central and color vision and visual acuity. Mutations in the channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophy. We investigated the gene expression profiles in mouse retina with CNG channel deficiency on a cone-dominant background, i.e., CNGA3-/-/Nrl-/- and CNGB3-/-/Nrl-/- mice, relative to Nrl-/- mice.
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| Overall design |
Total RNA was isolated from 2 retinas per animal (CNGA3-/-/Nrl-/-, CNGB3-/-/Nrl-/-, and Nrl-/- mice). The background strain for these mutations was C57bl/6.
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| Contributor(s) |
Frank B, Ding X |
| Citation(s) |
23740940 |
| Submission date |
Sep 19, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Bart Frank |
| E-mail(s) |
frank@omrf.org
|
| Organization name |
OMRF
|
| Street address |
825 NE 13 St
|
| City |
Oklahoma City |
| State/province |
OK |
| ZIP/Postal code |
73103 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA175488 |
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