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Series GSE40999 Query DataSets for GSE40999
Status Public on Sep 19, 2013
Title Th2 cytokine IL-4 is critical in initiating pulmonary vascular inflammation under hypoxic conditions and induces pulmonary vascular endothelial cell activation.
Organism Mus musculus
Experiment type Expression profiling by array
Summary IL-4-mediated pro-inflammatory vascular responses have been implicated in the pathogenesis of chronic cardiopulmonary diseases.
Our results show that hypoxia-induced collagen synthesis and early recruitment of inflammatory cells are significantly less in the lungs of IL-4 knockout (KO) mice than in those of wild-type mice. In addition, we found that IL-4 significantly increased pro-inflammatory genes in primary pulmonary microvascular endothelial cells.
Overall design This study was designed to identify the gene expression profile of IL-4-dependent pulmonary vascular inflammation induced by hypoxia.
Contributor(s) Cheadle C, Kegan K
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Submission date Sep 19, 2012
Last update date Jun 14, 2018
Contact name chris cheadle
Phone 4105505984
Organization name JHU
Department SOM
Lab JHBMC Genomics Core
Street address 5200 Eastern Ave
City baltimore
State/province MD
ZIP/Postal code 21224
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (18)
GSM1006633 RJ7-1
GSM1006634 RJ7-2
GSM1006635 RJ7-3
BioProject PRJNA175515

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40999.txt.gz 132 b (ftp)(http) TXT
GSE40999_RAW.tar 3.1 Mb (http)(custom) TAR
GSE40999_non-normalized.txt.gz 2.1 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record

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